Recommended treatment duration:
A dose recommendation cannot be made for patients with severe renal impairment or end stage renal disease.
Lactation: It is not known whether Ledipasvir and Sofosbuvir and its metabolites are present in human breast milk.
Use with other drugs containing sofosbuvir, is not recommended
Geriatric Use: No overall differences in safety or effectiveness were observed between these subjects and younger subjects, and other reported clinical experience has not identified differences in responses between the elderly and younger patients. No dosage adjustment of Ledipasvir and Sofosbuvir is warranted in geriatric patients.
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