Regonix 40 mg (Regorafenib) Tablets

Introduction:

Regonix 40 mg, manufactured by Beacon Pharmaceuticals Ltd and supplied by Orio Pharma, is an advanced oral therapy used to treat various forms of cancer, including metastatic colorectal cancer (CRC), gastrointestinal stromal tumors (GIST), and hepatocellular carcinoma (HCC). Containing Regorafenib, Regonix 40 mg is a multi-kinase inhibitor that targets multiple protein kinases involved in tumor growth, angiogenesis, and metastatic progression. This medication provides a critical option for patients with advanced cancers who have progressed on or are intolerant to previous treatments, offering a targeted approach that improves survival and quality of life.

Manufacturing Excellence of Beacon Pharmaceuticals Ltd.:

Beacon Pharmaceuticals Ltd. is committed to producing high-quality pharmaceutical products that adhere to stringent international standards. The development of Regonix 40 mg reflects Beacon’s dedication to advancing oncology treatments through innovative research, rigorous quality control, and adherence to best manufacturing practices. Their focus on safety and efficacy ensures that Regonix 40 mg is a reliable and effective option for managing advanced cancers.

Mechanism of Action:

Regonix 40 mg contains Regorafenib, a potent multi-kinase inhibitor that works by blocking the activity of several enzymes that promote cancer cell proliferation, angiogenesis (formation of new blood vessels), and metastasis. Specifically, Regorafenib targets protein kinases involved in the vascular endothelial growth factor receptors (VEGFR1, VEGFR2, VEGFR3), platelet-derived growth factor receptors (PDGFR), and fibroblast growth factor receptors (FGFR), among others. By inhibiting these pathways, Regonix 40 mg helps to slow tumor growth, reduce tumor vascularization, and limit the spread of cancer to other parts of the body.

Clinical Applications:

Regonix 40 mg is indicated for the treatment of:

• Metastatic Colorectal Cancer (CRC): Regonix 40 mg is used in adult patients with metastatic colorectal cancer who have been previously treated with fluoropyrimidine-, oxaliplatin-, and irinotecan-based chemotherapy, an anti-VEGF therapy, and, if RAS wild-type, an anti-EGFR therapy.
• Gastrointestinal Stromal Tumors (GIST): Regonix 40 mg is indicated for the treatment of patients with locally advanced, unresectable, or metastatic GIST who have progressed on or are intolerant to previous treatments with imatinib and sunitinib.
• Hepatocellular Carcinoma (HCC): Regonix 40 mg is also used in patients with hepatocellular carcinoma who have been previously treated with sorafenib.

Clinical studies have demonstrated that Regorafenib significantly improves progression-free survival in patients with these advanced cancers, making it a valuable option in the management of difficult-to-treat malignancies.

Dosage and Administration:

The recommended dosage of Regonix 40 mg is typically 160 mg (four 40 mg tablets) taken once daily for the first 21 days of each 28-day cycle. The tablets should be taken at the same time each day, with a low-fat meal. It is crucial for patients to adhere to the prescribed dosing schedule and follow their healthcare provider’s instructions carefully to achieve the best possible outcomes. Regular monitoring of liver function, blood pressure, and overall health is necessary to assess the response to therapy and manage any potential side effects.

Benefits of Regonix 40 mg:

• Targeted Cancer Therapy: Regonix 40 mg offers a precision treatment option for patients with advanced colorectal cancer, GIST, and hepatocellular carcinoma, targeting multiple pathways involved in tumor growth and spread.
• Improved Survival Rates: Clinical evidence shows that Regonix 40 mg significantly extends progression-free survival in patients with advanced cancers, offering hope to those with limited treatment options.
• Convenient Oral Administration: The oral dosage form of Regonix 40 mg allows for at-home treatment, promoting patient adherence and convenience.
• Well-Tolerated: Regonix 40 mg has a favorable safety profile, making it suitable for long-term use under proper medical supervision, with manageable side effects that are regularly monitored.

Supplier: Orio Pharma

Orio Pharma ensures that Regonix 40 mg is readily available to healthcare providers and patients, offering reliable access to this critical cancer therapy. Their commitment to efficient supply and distribution supports effective management of metastatic colorectal cancer, GIST, and hepatocellular carcinoma, helping to improve patient outcomes.

Conclusion:

Regonix 40 mg (Regorafenib) by Beacon Pharmaceuticals Ltd, supplied by Orio Pharma, represents a significant advancement in the treatment of metastatic colorectal cancer, gastrointestinal stromal tumors, and hepatocellular carcinoma. This targeted therapy offers an effective and convenient option for managing these challenging cancers, improving progression-free survival and enhancing quality of life. By incorporating Regonix 40 mg into their treatment plans, healthcare providers can offer patients a reliable and effective strategy for managing advanced cancers, ultimately leading to better health outcomes and extended survival.