Introduction

Gemtor 200 mg Injection is a premium-quality gemcitabine formulation manufactured by Eskayef Pharmaceuticals Ltd., one of Bangladesh’s leading pharmaceutical companies. This critical oncology medication is supplied worldwide by Orio Pharma, ensuring that healthcare providers and patients have access to essential cancer treatments with reliable 3-7 day global delivery.

How Gemtor Works

Gemtor (Gemcitabine) is an advanced antimetabolite that effectively targets cancer cells through multiple mechanisms:

• Inhibits DNA synthesis by blocking cells at the G1/S-phase boundary
• Metabolizes into active diphosphate (dFdCDP) and triphosphate (dFdCTP) nucleosides
• dFdCDP inhibits ribonucleotide reductase, disrupting cancer cell DNA synthesis
• dFdCTP competes with dCTP for incorporation into DNA through self-potentiation
• Triggers apoptotic cell death after incorporation into DNA strands

This multi-targeted approach makes Gemtor an essential component in various cancer treatment protocols, offering healthcare providers a powerful tool in their oncology arsenal.

Therapeutic Applications

Gemtor 200 mg has demonstrated significant efficacy in multiple cancer types:

Ovarian Cancer

• Combined with carboplatin for advanced ovarian cancer
• Specifically for cases that have relapsed at least 6 months after platinum-based therapy
• Offers new hope for patients with recurrent disease

Breast Cancer

• Used with paclitaxel for first-line treatment of metastatic breast cancer
• Particularly effective after failure of anthracycline-containing adjuvant chemotherapy
• Alternative option when anthracyclines are clinically contraindicated

Non-Small Cell Lung Cancer

• Paired with cisplatin to create a potent combination therapy
• Targets rapidly dividing cancer cells in lung tissue
• Part of standard treatment protocols for this challenging cancer type

Pancreatic Cancer

• Administered as a single-agent therapy
• Proven efficacy in one of the most difficult-to-treat cancer types
• Extends survival and improves quality of life in eligible patients

Dosage Recommendations

Gemtor’s dosing schedule is carefully calibrated for each cancer type to maximize effectiveness while managing side effects:

Ovarian Cancer: 1000 mg/m² administered over 30 minutes on Days 1 and 8 of each 21-day treatment cycle

Breast Cancer: 1250 mg/m² administered over 30 minutes on Days 1 and 8 of each 21-day treatment cycle

Non-Small Cell Lung Cancer: Either 1000 mg/m² over 30 minutes on Days 1, 8, and 15 of each 28-day cycle or 1250 mg/m² over 30 minutes on Days 1 and 8 of each 21-day cycle

Pancreatic Cancer: 1000 mg/m² over 30 minutes once weekly for 7 weeks, followed by one week of rest, then once weekly for 3 weeks of each subsequent 28-day cycle

Clinical Considerations

Contraindications

Gemtor should not be administered to patients with known hypersensitivity to gemcitabine or any components of the formulation.

Important Safety Information

• Schedule-dependent toxicity: Maintain recommended infusion times (<60 minutes) and dosing frequency
• Myelosuppression: Regular monitoring of blood counts is essential before each cycle
• Pulmonary toxicity: Discontinue immediately for unexplained dyspnea or severe pulmonary issues
• Hemolytic-Uremic Syndrome: Monitor renal function and discontinue if HUS develops
• Pregnancy Category D: Can cause fetal harm; not recommended during pregnancy
• Breastfeeding: Not recommended during treatment due to potential risks to the infant

Common Side Effects

Patients and healthcare providers should be aware of potential side effects, including:

• Nausea and vomiting
• Hematological effects (anemia, neutropenia, thrombocytopenia)
• Elevated liver enzymes (transaminitis)
• Increased alkaline phosphatase
• Proteinuria and hematuria
• Fever and rash
• Breathing difficulties (dyspnea)
• Peripheral edema

Storage and Handling

For maximum stability and efficacy, Gemtor 200 mg should be stored:

• Below 30°C temperature
• Protected from light
• Away from moisture
• Out of reach of children

Why Choose Gemtor from Orio Pharma?

1. Quality Assurance: Manufactured by Eskayef Pharmaceuticals Ltd., with over 31 years of pharmaceutical excellence
2. Reliable Supply Chain: Orio Pharma specializes in oncology medications since 2019
3. Global Availability: Fast worldwide shipping within 3-7 working days
4. Dedication to Patient Care: Supporting healthcare providers with essential cancer treatments
5. Comprehensive Support: Professional guidance on storage, handling, and administration

Healthcare professionals trust Gemtor 200 mg for its consistent quality, reliable efficacy, and comprehensive support from both the manufacturer and supplier. When selecting gemcitabine treatments for cancer patients, Gemtor represents a dependable choice backed by years of clinical experience and pharmaceutical expertise.

For prescribing information, additional clinical data, or to place an order, contact Orio Pharma’s specialized oncology support team today.