Enacitib 50 mg (Enasidenib) Tablets

Introduction:

Enacitib 50 mg, manufactured by Ziska Pharmaceuticals Ltd and supplied by Orio Pharma, is an innovative targeted therapy designed for the treatment of acute myeloid leukemia (AML) in patients with an isocitrate dehydrogenase-2 (IDH2) mutation. Containing Enasidenib, Enacitib 50 mg specifically targets and inhibits the mutated IDH2 enzyme, which plays a crucial role in the development and progression of AML. This medication provides a critical option for patients with IDH2-mutated AML, offering a targeted approach that can induce remission and improve survival rates.

Manufacturing Excellence of Ziska Pharmaceuticals Ltd.:

Ziska Pharmaceuticals Ltd. is dedicated to producing high-quality pharmaceutical products that meet stringent international standards. The development of Enacitib 50 mg reflects Ziska’s commitment to advancing oncology therapies through innovative research, rigorous quality control, and adherence to best manufacturing practices. Their focus on safety and efficacy ensures that Enacitib 50 mg is a reliable and effective option for patients with IDH2-mutated AML.

Mechanism of Action:

Enacitib 50 mg contains Enasidenib, an oral inhibitor of the IDH2 enzyme. In patients with AML, mutations in the IDH2 gene lead to the production of an abnormal version of the enzyme, which contributes to the accumulation of an oncometabolite called 2-hydroxyglutarate (2-HG). This oncometabolite interferes with normal cell differentiation, promoting the growth of leukemia cells. By inhibiting the mutated IDH2 enzyme, Enasidenib reduces the levels of 2-HG, allowing normal differentiation of hematopoietic cells and leading to the reduction of leukemic blasts in the bone marrow.

Clinical Applications:

Enacitib 50 mg is indicated for the treatment of:

• IDH2-Mutated Acute Myeloid Leukemia (AML): Enacitib 50 mg is used in adult patients with relapsed or refractory AML who have a confirmed IDH2 mutation. It provides a targeted treatment option that addresses the specific genetic driver of the disease.

Clinical studies have demonstrated that Enasidenib can lead to durable remissions and significant reductions in leukemic cells, making it an essential therapy for patients with IDH2-mutated AML.

Dosage and Administration:

The recommended dosage of Enacitib 50 mg is one tablet taken once daily. The tablet should be swallowed whole with water, with or without food. It is crucial for patients to adhere to the prescribed dosing schedule and follow their healthcare provider’s instructions carefully to achieve the best possible outcomes. Regular monitoring of blood counts, liver function, and overall health is essential to assess the response to therapy and manage any potential side effects.

Benefits of Enacitib 50 mg:

• Targeted AML Therapy: Enacitib 50 mg offers a precision treatment option for patients with IDH2-mutated AML, targeting the underlying genetic mutation that drives the disease.
• Induces Remission: Clinical evidence shows that Enacitib 50 mg can induce remission in patients with relapsed or refractory AML, offering a lifeline to those with limited treatment options.
• Oral Administration: The convenient oral dosage form of Enacitib 50 mg allows for easy at-home treatment, promoting patient adherence and comfort.
• Well-Tolerated: Enacitib 50 mg has a favorable safety profile, making it suitable for long-term use in managing AML under proper medical supervision.

Supplier: Orio Pharma

Orio Pharma ensures that Enacitib 50 mg is readily available to healthcare providers and patients, offering reliable access to this critical AML therapy. Their commitment to efficient supply and distribution supports effective management of IDH2-mutated AML, helping to improve patient outcomes.

Conclusion:

Enacitib 50 mg (Enasidenib) by Ziska Pharmaceuticals Ltd, supplied by Orio Pharma, represents a significant advancement in the treatment of IDH2-mutated acute myeloid leukemia. This targeted therapy offers an effective and convenient option for managing this specific genetic subtype of AML, improving remission rates and enhancing quality of life. By incorporating Enacitib 50 mg into their treatment plans, healthcare providers can offer patients a reliable and effective strategy for managing advanced AML, ultimately leading to better health outcomes and long-term survival.